Can I use Drizzle or Prisma with Supabase without supabase-js?

Yes. Drizzle, Prisma, and other ORMs can connect with a standard Postgres connection string, so you can use these without supabase-js. The client library is only for the Data API, Auth, Storage, and Realtime.

For more details, refer to the dedicated guides on Drizzle and Prisma.